Dichloromethane → 4-(4-chloro-1-ethylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]thiophene-2-carboxamide

HRID 185672Notes

Reaction equation

HRID 185672 reaction equation
[CH:42]([N:43]([CH2:44][CH3:45])[CH:46]([CH3:47])[CH3:48])([CH3:49])[CH3:50].[Cl:1][c:2]1[cH:3][n:4][n:5]([CH2:15][CH3:16])[c:6]1-[c:7]1[cH:8][c:9]([C:12](=[O:13])[OH:14])[s:10][cH:11]1.[Cl:51][CH2:52][Cl:53].[NH2:17][CH:18]([CH2:19][N:20]1[C:21](=[O:30])[c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[C:28]1=[O:29])[CH2:31][c:32]1[c:33]([C:38]([F:39])([F:40])[F:41])[cH:34][cH:35][cH:36][cH:37]1>>[Cl:1][c:2]1[cH:3][n:4][n:5]([CH2:15][CH3:16])[c:6]1-[c:7]1[cH:8][c:9]([C:12](=[O:14])[NH:17][CH:18]([CH2:19][N:20]2[C:21](=[O:30])[c:22]3[cH:23][cH:24][cH:25][cH:26][c:27]3[C:28]2=[O:29])[CH2:31][c:32]2[c:33]([C:38]([F:39])([F:40])[F:41])[cH:34][cH:35][cH:36][cH:37]2)[s:10][cH:11]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 670661664-(4-chloro-1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxylic acidHCID 1785107622-[2-amino-3-[2-(trifluoromethyl)phenyl]propyl]isoindole-1,3-dione

Product 1

HCID 1784630944-(4-chloro-1-ethylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]thiophene-2-carboxamide

Sources & evidence

ORD record
ord-9594eb0b944d4988843564cf788c4a6c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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