反应详情

To a solution of N,N-carbonyldiimidazole (139 g) and imidazole (117 g) in dimethylsulfoxide (2 liters) is added with stirring 6-(3-aminopropoxy)carbostyril (200 g) in portions under ice-cooling. The mixture is further stirred at room temperature for one day, and poured into ice-water. The precipitated crystals are collected by filtration, and washed with water. The crystals thus obtained are further washed successively with ethanol and diethyl ether, and dried to give 6-[3-(1-imidazolyl)carbonylaminopropoxy]carbostyril (162 g) as a white powder.

1. temperaturecooling
2. filtrationThe precipitated crystals are collected by filtration
3. washwashed with water
4. customThe crystals thus obtained
5. washare further washed successively with ethanol and diethyl ether
6. customdried