反应详情

To a suspension of lithium aluminum hydride (1.9 g) in anhydrous tetrahydrofuran (50 ml) is added dropwise with stirring a solution of 6-(3-azidopropoxy)carbostyril (10 g) in anhydrous tetrahydrofuran (200 ml) under ice-cooling. The mixture is stirred at room temperature for one hour, and thereto are added dropwise water (2 ml), a 15% aqueous sodium hydroxide solution (2 ml) and water (6 ml). The insoluble materials are collected by filtration, and added to a mixture of chloroform-methanol (8: 1). The mixture is heated, and then cooled. The insoluble material are removed by filtration. The filtrate is concentrated under reduced pressure to remove the solvent, and thereto is added diethyl ether. The precipitated crystals are collected by filtration to give 6-(3-aminopropoxy)carbostyril (6.2 g) as a white powder.

1. additionis added dropwise
2. temperaturecooling
3. filtrationThe insoluble materials are collected by filtration
4. additionadded to a mixture of chloroform-methanol (8: 1)
5. temperatureThe mixture is heated
6. temperaturecooled
7. customThe insoluble material are removed by filtration
8. concentrationThe filtrate is concentrated under reduced pressure
9. customto remove the solvent
10. additionis added diethyl ether
11. filtrationThe precipitated crystals are collected by filtration