HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-propanol → 6-[3-(2-Hydroxypropyl)aminopropoxy]carbostyril
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-propanol | HCID 4 | — |
| Reactant | 6-(3-Chloropropoxy)carbostyril | HCID 14289480 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 6-[3-(2-Hydroxypropyl)aminopropoxy]carbostyril | HCID 22132612 | — |
Reaction Steps
6-(3-Chloropropoxy)carbostyril (5 g) and 1-amino-2-propanol (24 ml) are dissolved in 2-propanol (100 ml), and the mixture is refluxed for 4 hours. After the reaction mixture is allowed to cool, the precipitated crystals are collected by filtration, washed with ethanol, and dried to give 6-[3-(2-hydroxypropyl)aminopropoxy]carbostyril (3.1 g) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143763 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-a66b798be5f1449780fce0489f7550c2 |
| Source note | uspto-grants-2000_11 |