反应详情

6-(3-Chloropropoxy)carbostyril (5 g) and 1-amino-2-propanol (24 ml) are dissolved in 2-propanol (100 ml), and the mixture is refluxed for 4 hours. After the reaction mixture is allowed to cool, the precipitated crystals are collected by filtration, washed with ethanol, and dried to give 6-[3-(2-hydroxypropyl)aminopropoxy]carbostyril (3.1 g) as a white powder.

1. temperaturethe mixture is refluxed for 4 hours
2. temperatureto cool
3. filtrationthe precipitated crystals are collected by filtration
4. washwashed with ethanol
5. customdried