1-Amino-2-propanol → 6-[3-(2-Hydroxypropyl)aminopropoxy]carbostyril

HRID 1856763Notes

Reaction equation

HRID 1856763 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2.[NH2:17][CH2:18][CH:19]([OH:21])[CH3:20]>CC(O)C>[OH:21][CH:19]([CH3:20])[CH2:18][NH:17][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH:10]=[CH:9]2

Participants

4

Reactant 2

HCID 41-Amino-2-propanolHCID 142894806-(3-Chloropropoxy)carbostyril

Product 1

HCID 221326126-[3-(2-Hydroxypropyl)aminopropoxy]carbostyril

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

6-(3-Chloropropoxy)carbostyril (5 g) and 1-amino-2-propanol (24 ml) are dissolved in 2-propanol (100 ml), and the mixture is refluxed for 4 hours. After the reaction mixture is allowed to cool, the precipitated crystals are collected by filtration, washed with ethanol, and dried to give 6-[3-(2-hydroxypropyl)aminopropoxy]carbostyril (3.1 g) as a white powder.

Workup

  1. temperaturethe mixture is refluxed for 4 hours
  2. temperatureto cool
  3. filtrationthe precipitated crystals are collected by filtration
  4. washwashed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-a66b798be5f1449780fce0489f7550c2
Source dataset
uspto-grants-2000_11
Patent number
US06143763

Reaction notes

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