反应详情

A solution of 6-(3-chloropropoxy)carbostyril (5.0 g) and 3-amino-1-propanol (24 ml) in methanol (25 ml) is heated at 100° C. for 4 hours in an autoclave. The mixture is concentrated under reduced pressure to remove the solvent, and the residue is purified by silica gel column chromatography (solvent; methylene chloride:methanol:aqueous ammonia=70:10:1), and recrystallized from methanol-diethyl ether to give 6-[3-(3-hydroxypropyl)aminopropoxy]carbostyril(4.4 g) as a white powder.

1. concentrationThe mixture is concentrated under reduced pressure
2. customto remove the solvent
3. customthe residue is purified by silica gel column chromatography (solvent; methylene chloride:methanol:aqueous ammonia=70:10:1)
4. customrecrystallized from methanol-diethyl ether