HCID 15380638, compound → HCID 15380639, compound

HRID 1856842Notes

Reaction equation

HRID 1856842 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:30]=[CH:31][CH:32]=1)[CH2:7][NH:8][C:9]([C:11]1[CH:15]=[C:14]([CH2:16][CH3:17])[S:13][C:12]=1[NH:18][C:19]([CH:21]1[CH2:26][CH2:25][CH:24]([C:27]([OH:29])=[O:28])[CH2:23][CH2:22]1)=[O:20])=[O:10])([O-])=O>CO.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:30]=[CH:31][CH:32]=1)[CH2:7][NH:8][C:9]([C:11]1[CH:15]=[C:14]([CH2:16][CH3:17])[S:13][C:12]=1[NH:18][C:19]([CH:21]1[CH2:26][CH2:25][CH:24]([C:27]([OH:29])=[O:28])[CH2:23][CH2:22]1)=[O:20])=[O:10]

Participants

4

Reactant 1

HCID 15380638HCID 15380638, compound

Product 1

HCID 15380639HCID 15380639, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 4-{3-[(3-nitrobenzyl)carbamoyl]-5-ethylthiophen-2-ylcarbamoyl}cyclohexanecarboxylic acid in methanol is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. After recrystallization, 4-{3-[(3-aminobenzyl)carbamoyl]-5-ethylthiophen-2-ylcarbamoyl}cyclohexanecarboxylic acid is obtained.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe solution is concentrated
  3. customAfter recrystallization

Sources & evidence

ORD record
ord-f1468b241cd64e888db57444a9accee6
Source dataset
uspto-grants-2000_11
Patent number
US06143777

Reaction notes

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