m-Chloroperbenzoic acid → HCID 19609114, compound

HRID 1856845Notes

Reaction equation

HRID 1856845 reaction equation
[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([S:22][CH3:23])[N:14]=[C:13]2[CH2:24][CH2:25][CH3:26])=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1.ClC1C=CC=C(C(OO)=[O:35])C=1>C(Cl)Cl>[Cl:1][C:2]1[C:3]([CH2:11][N:12]2[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[C:15]([S:22]([CH3:23])=[O:35])[N:14]=[C:13]2[CH2:24][CH2:25][CH3:26])=[CH:4][C:5]2[O:9][CH2:8][O:7][C:6]=2[CH:10]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 54272883HCID 54272883, compound

Product 1

HCID 19609114HCID 19609114, compoundYield 91.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9.26 g of the product obtained in Stage 4 above is introduced into 400 ml of methylene chloride at 0° C. and 5.8 g of metachloroperbenzoic acid is added. Agitation is carried out for one hour at ambient temperature and the reaction medium is washed with sodium and potassium hydride, followed by extraction with methylene chloride, washing with water, drying and evaporating the solvent. After chromatography 8.8 g of expected product is obtained. M.p.=187° C.

Workup

  1. washthe reaction medium is washed with sodium and potassium hydride
  2. extractionfollowed by extraction with methylene chloride
  3. washwashing with water
  4. customdrying
  5. customevaporating the solvent

Sources & evidence

ORD record
ord-a2508c8c64e946f5a16b9d681905ed7f
Source dataset
uspto-grants-2000_11
Patent number
US06143774

Reaction notes

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