Hydrochloric Acid → HCID 53855529, compound

HRID 1856910Notes

Reaction equation

HRID 1856910 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:19]=[C:20]([O:22][CH3:23])[CH:21]=1)[CH:17]=O.Cl>CO>[CH3:23][O:22][C:20]1[CH:19]=[C:16]([CH:17]=[C:7]2[C:6](=[O:9])[C:5]3[CH:10]=[CH:11][C:2]([OH:1])=[CH:3][C:4]=3[O:8]2)[CH:15]=[C:14]([O:13][CH3:12])[CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 817473,5-DimethoxybenzaldehydeHCID 2357176-Hydroxy-3-coumaranone

Product 1

HCID 53855529HCID 53855529, compoundYield 71.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3,5-dimethoxybenzaldehyde 1.23 g were dissolved in methanol 75 ml, concentrated hydrochloric acid 50 ml was added, and the mixture was refluxed for 1.5 hours. The solution was cooled to room temperature, and precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure to obtain the desired compound 1.42 g.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. customprecipitated crystals
  3. filtrationwere filtered
  4. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure

Sources & evidence

ORD record
ord-d3efd5005e8b4e57b6e3a474ea5858d6
Source dataset
uspto-grants-2000_11
Patent number
US06143779

Reaction notes

Loading…