Hydrochloric Acid → HCID 908515, compound

HRID 1856922Notes

Reaction equation

HRID 1856922 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH:17]=O.Cl.CO>C(O)(=O)C>[CH3:12][O:13][C:14]1[CH:15]=[C:16](/[CH:17]=[C:7]2/[O:8][C:4]3[CH:3]=[C:2]([OH:1])[CH:11]=[CH:10][C:5]=3[C:6]/2=[O:9])[CH:19]=[CH:20][C:21]=1[O:22][CH3:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 8419VeratraldehydeHCID 2357176-Hydroxy-3-coumaranone

Product 1

HCID 908515HCID 908515, compoundYield 41.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3,4dimethoxybenzaldehyde 1.23 g were dissolved in acetic acid 20 ml, concentrated hydrochloric acid 1.1 ml was added, and the mixture was stirred for 18 hours, and methanol 15 ml was added. Precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure to obtain the desired compound 0.82 g.

Workup

  1. customPrecipitated crystals
  2. filtrationwere filtered
  3. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure

Sources & evidence

ORD record
ord-42f56a9d290f466bae44af1afe70bd5a
Source dataset
uspto-grants-2000_11
Patent number
US06143779

Reaction notes

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