Hydrochloric Acid → HCID 53964639, compound

HRID 1856923Notes

Reaction equation

HRID 1856923 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[CH2:12]([O:14][C:15]1[CH:16]=[C:17]([CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH:18]=O)[CH3:13].Cl.O>CO>[CH2:12]([O:14][C:15]1[CH:16]=[C:17]([CH:18]=[C:7]2[C:6](=[O:9])[C:5]3[CH:10]=[CH:11][C:2]([OH:1])=[CH:3][C:4]=3[O:8]2)[CH:20]=[CH:21][C:22]=1[O:23][CH3:24])[CH3:13]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2357176-Hydroxy-3-coumaranoneHCID 2447283-Ethoxy-4-methoxybenzaldehyde

Product 1

HCID 53964639HCID 53964639, compoundYield 47.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3-ethoxy-4-methoxybenzaldehyde 1.33 g were dissolved in methanol 75 ml, concentrated hydrochloric acid 50 ml was added, and the mixture was refluxed for 1.5 hours. The solution was cooled to room temperature, and water 150 ml was added. Precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure to obtain the desired compound 0.99 g.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. customPrecipitated crystals
  3. filtrationwere filtered
  4. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure

Sources & evidence

ORD record
ord-3125237d1c044622b5110a78fa0cbe0f
Source dataset
uspto-grants-2000_11
Patent number
US06143779

Reaction notes

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