Hydrochloric Acid → HCID 53796317, compound

HRID 1856925Notes

Reaction equation

HRID 1856925 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[CH3:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][C:20]=1[OH:21])[CH:16]=O.Cl.O>CO>[CH3:12][C:13]1[CH:14]=[C:15]([CH:16]=[C:7]2[C:6](=[O:9])[C:5]3[CH:10]=[CH:11][C:2]([OH:1])=[CH:3][C:4]=3[O:8]2)[CH:18]=[CH:19][C:20]=1[OH:21]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 1399014-Hydroxy-3-methylbenzaldehydeHCID 2357176-Hydroxy-3-coumaranone

Product 1

HCID 53796317HCID 53796317, compoundYield 68.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3-methyl-4-hydroxybenzaldehyde 1.00 g were dissolved in methanol 70 ml, concentrated hydrochloric acid 60 ml was added, and the mixture was refluxed for 1.5 hours. The solution was cooled to room temperature, and water 250 ml was added. Precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure to obtain the desired compound 1.22 g.

Workup

  1. temperaturethe mixture was refluxed for 1.5 hours
  2. customPrecipitated crystals
  3. filtrationwere filtered
  4. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure

Sources & evidence

ORD record
ord-e809ee4078e94746b9cf219ec6a23cf8
Source dataset
uspto-grants-2000_11
Patent number
US06143779

Reaction notes

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