Hydrochloric Acid → HCID 53981279, compound

HRID 1856952Notes

Reaction equation

HRID 1856952 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[CH2:7][O:8][C:4]=2[CH:3]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[O:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH:17]=O.Cl>CO>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:17]=[C:7]2[C:6](=[O:9])[C:5]3[CH:10]=[CH:11][C:2]([OH:1])=[CH:3][C:4]=3[O:8]2)[CH:19]=[CH:20][C:21]=1[O:22][CH2:23][CH2:24][CH2:25][CH3:26]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 2357176-Hydroxy-3-coumaranoneHCID 20638224-butoxy-3-methoxybenzaldehyde

Product 1

HCID 53981279HCID 53981279, compoundYield 42.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

After 6-hydroxy-2H-benzofuran-3-one 1 g and 3-methoxy-4-butoxybenzaldehyde 1.66 g were dissolved in methanol 60 ml, concentrated hydrochloric acid 50 ml was added, and the mixture was refluxed for 2.5 hours. After the solution was cooled to room temperature, the precipitated crystals were filtered and dried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure to obtain the desired compound 0.97 g.

Workup

  1. temperaturethe mixture was refluxed for 2.5 hours
  2. filtrationthe precipitated crystals were filtered
  3. dry with materialdried over phosphorous pentoxide at a temperature of 60° C. for four hours under reduced pressure

Sources & evidence

ORD record
ord-90303824dd4649559cc5d67da3122adc
Source dataset
uspto-grants-2000_11
Patent number
US06143779

Reaction notes

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