Trimethyl borate → HCID 54539041, compound

HRID 1856992Notes

Reaction equation

HRID 1856992 reaction equation
[CH2:1]([O:3][C:4]1[CH:14]=[C:13]([CH2:15][C:16]([NH:18][CH:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[N:29]2[CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[CH2:20][CH2:21][CH3:22])=[O:17])[CH:12]=[CH:11][C:5]=1[C:6](OCC)=[O:7])[CH3:2].[BH4-].[Li+].B(OC)(OC)OC>O1CCCC1>[CH2:1]([O:3][C:4]1[CH:14]=[C:13]([CH2:15][C:16]([NH:18][CH:19]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[N:29]2[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]2)[CH2:20][CH2:21][CH3:22])=[O:17])[CH:12]=[CH:11][C:5]=1[CH2:6][OH:7])[CH3:2]

Participants

5

Reactant 3

HCID 8470Trimethyl borateHCID 4148881Lithium borohydrideHCID 10504402HCID 10504402, compound

Product 1

HCID 54539041HCID 54539041, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from ethyl 2-ethoxy-4-[N-{1-(2-piperidino-phenyl)-1-butyl}-aminocarbonylmethyl]-benzoate by reduction with lithium borohydride in boiling tetrahydrofuran in the presence of 10% of trimethyl borate.

Sources & evidence

ORD record
ord-16af0468c4fb4d17a796bda3786b767c
Source dataset
uspto-grants-2000_11
Patent number
US06143769

Reaction notes

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