Hydrochloric Acid → HCID 10648847, compound

HRID 1857005Notes

Reaction equation

HRID 1857005 reaction equation
[CH2:1]([O:3][C:4]1[CH:14]=[C:13]([CH2:15][C:16]([NH:18][C:19]([CH3:38])(C2CCCCC2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[O:17])[CH:12]=[CH:11][C:5]=1[C:6]([O:8]CC)=[O:7])[CH3:2].[OH-].[Na+].Cl>C(O)C>[CH2:1]([O:3][C:4]1[CH:14]=[C:13]([CH2:15][C:16]([NH:18][CH:19]([CH2:38][CH:4]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:5]2)[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)=[O:17])[CH:12]=[CH:11][C:5]=1[C:6]([OH:8])=[O:7])[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21261839HCID 21261839, compound

Product 1

HCID 10648847HCID 10648847, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-ethoxy-4-[N-(α-cyclohexyl-methyl-2-piperidino-benzyl)-aminocarbonylmethyl]-benzoate (1.15 g, 2.21 mmol) in ethanol (12 ml) are stirred together with 1N sodium hydroxide solution (3.3 ml) for 2 hours at 50° C. Then 1N hydrochloric acid (3.3 ml) is added and the mixture is cooled in ice. The precipitate formed is filtered off, washed with a little ice cold ethanol and dried in vacuo at 100° C.

Workup

  1. temperaturethe mixture is cooled in ice
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. washwashed with a little ice cold ethanol
  5. customdried in vacuo at 100° C.

Sources & evidence

ORD record
ord-d039b9b620f84cc993dfe2133bbdcfee
Source dataset
uspto-grants-2000_11
Patent number
US06143769

Reaction notes

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