Methanol → 3-Methyl-1-(2-piperidinophenyl)-1-butylamine, (S)-

HRID 1857022Notes

Reaction equation

HRID 1857022 reaction equation
[CH3:1][CH:2]([CH3:18])[CH2:3][CH:4]([NH2:17])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(N[C@H](C(O)=O)CCC(O)=O)(=O)C.CO>CC(C)=O>[CH3:1][CH:2]([CH3:18])[CH2:3][C@H:4]([NH2:17])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 887MethanolHCID 70914N-acetyl-L-glutamic acidHCID 104220523-Methyl-1-(2-piperidino-phenyl)-1-butylamine

Product 1

HCID 105146093-Methyl-1-(2-piperidinophenyl)-1-butylamine, (S)-

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Equimolar quantities of racemic 3-methyl-1-(2-piperidino-phenyl)-1-butylamine and of N-acetyl-L-glutamic acid were refluxed in aceton, whereby methanol was added in such an amount to yield a clear solution.

Workup

  1. customto yield a clear solution

Sources & evidence

ORD record
ord-7821eeb086974856b385f4462f33d457
Source dataset
uspto-grants-2000_11
Patent number
US06143769

Reaction notes

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