6-Methoxy-2-naphthol → HCID 15479025, compound

HRID 1857097Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]2[C:25](=[CH:26][CH:27]=1)[CH:24]=[C:23]([OH:28])[CH:22]=[CH:21]2>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:28][C:23]1[CH:22]=[CH:21][C:20]2[C:25](=[CH:26][CH:27]=[C:18]([O:17][CH3:16])[CH:19]=2)[CH:24]=1

Participants

Reactant 2

HCID 2886346-Methoxy-2-naphthol

HCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 15479025HCID 15479025, compoundYield 59%

Conditions

Temperature: 180 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (75 mg) and 6-methoxy-2-naphthol (174 mg) obtained in Example 1 were mixed and stirred at 180° C. for 30 minutes, and the reaction mixture was then purified by thin layer chromatography on silica gel (eluting with hexane/acetone (2/1)) to obtain 71 mg of the title compound (yield: 59%).

Workup

customthe reaction mixture was then purified by thin layer chromatography on silica gel (eluting with hexane/acetone (2/1))

Sources & evidence

ORD record: ord-19988ef91dfb443d946b13ef0f7b43d7
Source dataset: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06143764

Reaction notes

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