(4-Hydroxyphenyl)(4-methylphenyl)methanone → HCID 22132802, compound

HRID 1857117Notes

Reaction equation

HRID 1857117 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([C:25]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][CH:26]=2)=[O:24])=[CH:19][CH:18]=1>>[CH3:13][O:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:14][CH3:15])[N:5]=[CH:4][CH:3]=[C:2]2[O:31][C:28]1[CH:27]=[CH:26][C:25]([C:23]([C:20]2[CH:19]=[CH:18][C:17]([CH3:16])=[CH:22][CH:21]=2)=[O:24])=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 67258(4-Hydroxyphenyl)(4-methylphenyl)methanoneHCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 22132802HCID 22132802, compoundYield 74.2%

Conditions

Temperature
180 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (89 mg) and 4-hydroxyphenyl 4-methylphenyl ketone (248 mg) obtained in Example 25 were mixed and stirred at 180° C. for 10 minutes, and the reaction mixture was then purified in the same manner as described in Example 24 to obtain 118 mg of the title compound (yield: 74%).

Workup

  1. customthe reaction mixture was then purified in the same manner

Sources & evidence

ORD record
ord-e29aecdd52b440cba0f5ab4c18b179a8
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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