4-Chloro-6,7-dimethoxyquinoline → HCID 22132783, compound

HRID 1857118Notes

Reaction equation

HRID 1857118 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([Cl:31])[CH:26]=2)=[O:24])=[CH:19][CH:18]=1>>[Cl:31][C:27]1[CH:26]=[C:25]([C:23]([C:20]2[CH:19]=[CH:18][C:17]([O:16][C:2]3[C:11]4[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=4)[N:5]=[CH:4][CH:3]=3)=[CH:22][CH:21]=2)=[O:24])[CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 4596104-Chloro-6,7-dimethoxyquinolineHCID 122996723-Chlorophenyl 4-hydroxyphenyl ketone

Product 1

HCID 22132783HCID 22132783, compoundYield 40.1%

Conditions

Temperature
180 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (89 mg) and 3-chlorophenyl 4-hydroxyphenyl ketone (279 mg) obtained in Example 27 were mixed and stirred at 180° C. for 20 minutes. The reaction mixture was then purified in the same manner as described in Example 24 to obtain 67 mg of the title compound (yield: 40%).

Workup

  1. customThe reaction mixture was then purified in the same manner

Sources & evidence

ORD record
ord-685232a9b2a84a28bc1fbe0c1517b238
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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