4-Fluoro-4'-hydroxybenzophenone → HCID 22132711, compound

HRID 1857129Notes

Reaction equation

HRID 1857129 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][CH:3]=1.[OH:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([C:25]2[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=2)=[O:24])=[CH:19][CH:18]=1>>[F:31][C:28]1[CH:29]=[CH:30][C:25]([C:23]([C:20]2[CH:21]=[CH:22][C:17]([O:16][C:2]3[C:11]4[C:6](=[CH:7][C:8]([O:14][CH3:15])=[C:9]([O:12][CH3:13])[CH:10]=4)[N:5]=[CH:4][CH:3]=3)=[CH:18][CH:19]=2)=[O:24])=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 1176664-Fluoro-4'-hydroxybenzophenoneHCID 4596104-Chloro-6,7-dimethoxyquinoline

Product 1

HCID 22132711HCID 22132711, compoundYield 57%

Conditions

Temperature
170 °C

Procedure

4-Chloro-6,7-dimethoxyquinoline (112 mg) and commercially available 4-fluorophenyl 4-hydroxyphenyl ketone (324 mg) were mixed and stirred at 170° C. for 20 minutes. The reaction mixture was then purified in the same manner as described in Example 41 to obtain 114 mg of the title compound (yield: 57%).

Workup

  1. customThe reaction mixture was then purified in the same manner

Sources & evidence

ORD record
ord-e2d7ad932153454282fc5b6b45ac3f01
Source dataset
uspto-grants-2000_11
Patent number
US06143764

Reaction notes

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