反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (53 mg) was dissolved in toluene (3 ml) with heat, 4-trifluoromethylphenyl isocyanate (0.2 ml) was added, and the admixture was refluxed with heat for 10 minutes. The separated crystals were filtered and washed with toluene to obtain 77 mg of the title compound (yield: 88%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 10 minutes
4. filtrationThe separated crystals were filtered
5. washwashed with toluene