2-Nitrophenol → N-(4-Butylphenyl)-N'-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}urea

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Reaction Steps

6,7-Dimethoxy-4-(2-aminophenoxy)quinoline (56 mg), which was obtained, analogously to Example 49, by reducing 6,7-dimethoxy-4-(2-nitrophenoxy)quinoline obtained in the same manner as described in Example 48, except that 2-nitrophenol was used in place of 4-nitrophenol, was dissolved in toluene (3 ml) with heat, 4-n-butylphenyl isocyanate (0.2 ml) was added, and the admixture was refluxed with heat for 30 minutes. The resulting residue was purified by chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 45 mg of the title compound (yield: 50%).

Provenance & Evidence