HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichlorophenyl isocyanate → N-(2,4-Dichlorophenyl)-N'-(4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichlorophenyl isocyanate | HCID 75789 | — |
| Reactant | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(2,4-Dichlorophenyl)-N'-(4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea | HCID 11225456 | 85.4% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (53 mg) was dissolved in toluene (5 ml) with heat, 2,4-dichlorophenyl isocyanate (115 mg) was added, and the admixture was refluxed with heat for 20 minutes. The separated crystals were filtered and then washed with toluene to obtain 74 mg of the title compound (yield: 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-93138775865b49ba8b98f7fb900900bb |
| Source note | uspto-grants-2000_11 |