反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (54 mg) was dissolved in toluene (5 ml) with heat, 1-(1-naphthyl)ethyl isocyanate (0.05 ml) was added, and the admixture was refluxed with heat for 100 minutes. The resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 65 mg of the title compound (yield: 72%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 100 minutes
4. customThe resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1)