1-(1-Isocyanatoethyl)naphthalene → N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl)-N'-[1-(1-naphthyl)ethyl]urea

Participants

Reaction Steps

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (54 mg) was dissolved in toluene (5 ml) with heat, 1-(1-naphthyl)ethyl isocyanate (0.05 ml) was added, and the admixture was refluxed with heat for 100 minutes. The resulting residue was purified by column chromatography on silica gel eluting with chloroform/acetone (10/1) to obtain 65 mg of the title compound (yield: 72%).

Provenance & Evidence