反应详情

6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (123 mg) was dissolved in toluene (12 ml) with heat, 4-chloro-2-nitrophenyl isocyanate (172 mg) was added, and the admixture was refluxed with heat for 14 minutes. The separated crystals were filtered and then washed with toluene to obtain 174 mg of the title compound (yield: 85%).

1. temperaturewith heat
2. temperaturethe admixture was refluxed
3. temperaturewith heat for 14 minutes
4. filtrationThe separated crystals were filtered
5. washwashed with toluene