HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-nitrophenyl isocyanate → N-(4-Chloro-2-nitrophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-nitrophenyl isocyanate | HCID 4247257 | — |
| Reactant | 4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline | HCID 11594543 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | N-(4-Chloro-2-nitrophenyl)-N'-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea | HCID 22132647 | 85% |
Reaction Steps
6,7-Dimethoxy-4-(4-aminophenoxy)quinoline (123 mg) was dissolved in toluene (12 ml) with heat, 4-chloro-2-nitrophenyl isocyanate (172 mg) was added, and the admixture was refluxed with heat for 14 minutes. The separated crystals were filtered and then washed with toluene to obtain 174 mg of the title compound (yield: 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06143764 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-ecca966c00e14bdda99cd97484f9fd01 |
| Source note | uspto-grants-2000_11 |