Methanol → HCID 53777441, compound

HRID 1857304Notes

Reaction equation

HRID 1857304 reaction equation
[CH2:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=O)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].CO.O.[NH2:16][NH2:17]>O>[CH2:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[N:16][N:17]=[CH:9][C:8]2[CH:11]=[CH:12][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:6][CH:7]=2)=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 887MethanolHCID 24654Hydrazine hydrate (1:1)HCID 577537Benzaldehyde, 4-(2-methylpropyl)-

Product 1

HCID 53777441HCID 53777441, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A 3-liter three-necked flask was charged with 638.5 g (3.94 mol) of 4-isobutylbenzaldehyde and 1 liter of methanol, which were stirred for mixing by a mechanical stirrer. While the reactor was cooled with water so as to maintain the temperature of the reaction solution below 50° C., 98.5 g (1.97 mol) of hydrazine monohydrate was slowly added dropwise. After the completion of addition, the reaction solution was heated under reflux for 30 minutes and then allowed to stand one day.

Workup

  1. additionfor mixing by a mechanical stirrer
  2. additionwas slowly added dropwise
  3. additionAfter the completion of addition
  4. temperaturethe reaction solution was heated
  5. temperatureunder reflux for 30 minutes

Sources & evidence

ORD record
ord-6b65e65b6db64adf886e03ee2763a856
Source dataset
uspto-grants-2000_11
Patent number
US06146822

Reaction notes

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