反应详情

To 0.80 g of methyl 3-(isoxazol-3-yl)-4-methylsulfonyl-2-methylbenzoate were added 8 ml of ethanol and 8 ml of a 1N sodium hydroxide solution to stir at room temperature for 2 days. The reaction solution was poured into ice water, acidified with hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, then with a saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solvent was distilled out under reduced pressure to give 0.56 g of the title compound as white crystals. m.p. 150-151° C.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialwith a saturated sodium chloride solution, and dried over anhydrous magnesium sulfate
4. distillationThe solvent was distilled out under reduced pressure