Hydrochloric Acid → HCID 22120069, compound
Reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][C:3]=1[NH2:4].[ClH:10]>CO>[ClH:10].[Br:1][C:2]1[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][C:3]=1[NH2:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
To a solution of 2,5-dibromoaniline (Aldrich, 1.5 g, 6 mmol) in methanol (5 mL) was added methanolic HCl (1M, 30 mL) at 4° C., then the reaction mixture was stirred at 25° C. for 30 minutes. The reaction mixture became a light brown solution with a white precipitate. The precipitate was collected by filtration, washed with diethylether (2 mL), and dried under vacuum to afford 1.6 g of 2,5-dibromoaniline hydrochloride (93% yield).
Workup
- filtrationThe precipitate was collected by filtration
- washwashed with diethylether (2 mL)
- customdried under vacuum
Sources & evidence
- ORD record
- ord-874970cea43a4b8085016153459a850d
- Source dataset
- uspto-grants-2000_11
- Patent number
- US06147063
Reaction notes
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