HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Butanoic acid, 2-[(2,3-dichlorophenyl)methylene]-3-oxo-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 2,3-Dichlorobenzaldehyde | HCID 35745 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Butanoic acid, 2-[(2,3-dichlorophenyl)methylene]-3-oxo-, methyl ester | HCID 54242386 | — |
Reaction Steps
17.5 g (100 mmol) of 2,3-dichlorobenzaldehyde and 11.6 g (100 mmol) of methyl acetoacetate are boiled in a water separator for 3 h with 1 ml of piperidine and 0.5 ml of HOAc in 350 ml of CH2Cl2. The mixture is then washed twice with water, dried over MgSO4 and concentrated. The residue crystallizes from petroleum ether/ether. Yield: 15.0 g (55%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06147087 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-fe47c5ef738b4b0ba637b2c480b1fe2a |
| Source note | uspto-grants-2000_11 |