反应详情

17.5 g (100 mmol) of 2,3-dichlorobenzaldehyde and 11.6 g (100 mmol) of methyl acetoacetate are boiled in a water separator for 3 h with 1 ml of piperidine and 0.5 ml of HOAc in 350 ml of CH2Cl2. The mixture is then washed twice with water, dried over MgSO4 and concentrated. The residue crystallizes from petroleum ether/ether. Yield: 15.0 g (55%)

1. washThe mixture is then washed twice with water
2. dry with materialdried over MgSO4
3. concentrationconcentrated
4. customThe residue crystallizes from petroleum ether/ether