Trifluoroacetic acid → HCID 53773095, compound

HRID 1857559Notes

Reaction equation

HRID 1857559 reaction equation
[C:1]([O:4][CH:5]([C:18]([O-:20])=[O:19])[C@@H:6]([C:15]([O-:17])=[O:16])[NH:7]C(OC(C)(C)C)=O)(=[O:3])[CH3:2].FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[C:1]([O:4][CH:5]([C:18]([OH:20])=[O:19])[C@@H:6]([C:15]([OH:17])=[O:16])[NH2:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86756037HCID 86756037, compound

Product 1

HCID 53773095HCID 53773095, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 202 mg (0.50 mmol) of the compound (4) obtained in Step 2 in chloroform (2 ml) was added 2 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 20 hours. The solvent was distilled off and the residue was purified by C18 silica gel column chromatography (RP-C18, distilled water) to give 43 mg of the title compound (9) (yield 45%).

Workup

  1. distillationThe solvent was distilled off
  2. distillationthe residue was purified by C18 silica gel column chromatography (RP-C18, distilled water)

Sources & evidence

ORD record
ord-997408a7214d47aa9eb1ae619d81b557
Source dataset
uspto-grants-2000_11
Patent number
US06147113

Reaction notes

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