反应详情

Lysine octanoate (35.0 g) was suspended in 300 ml of xylene using a 600-milliliter reaction vessel. The suspension was boiled through heating, and water formed through azeotropic distillation was removed outside the system. After it was identified that a stoichiometric amount of water was removed (reaction time 3 hours), the residue was cooled. Crystals precipitated were separated through filtration, and washed with 100 ml of a 50% ethanol solution. The crystals were recrystallized from a sulfuric acid aqueous solution to obtain 26.9 g of Nε -octanoyl lysine (yield 81.9%). This is designated Derivative B.

1. customa 600-milliliter reaction vessel
2. temperaturethrough heating
3. customwas removed outside the system
4. customwas removed
5. custom(reaction time 3 hours)
6. temperaturethe residue was cooled
7. customCrystals precipitated
8. customwere separated through filtration
9. washwashed with 100 ml of a 50% ethanol solution
10. customThe crystals were recrystallized from a sulfuric acid aqueous solution