Water → HCID 473918, compound

HRID 1857692Notes

Reaction equation

HRID 1857692 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH:16]=O)=[N:12][C:11]=2[CH:18]([CH3:20])[CH3:19])[CH:5]=[C:6]([CH3:8])[CH:7]=1.Cl.[NH2:22][OH:23].C([O-])(=O)C.[Na+].O>C(O)C>[CH3:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[N:14]([CH3:15])[C:13]([CH:16]=[N:22][OH:23])=[N:12][C:11]=2[CH:18]([CH3:20])[CH3:19])[CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 443297Hydroxyamine hydrochlorideHCID 4739145-(3,5-Dimethylphenylthio)-4-isopropyl-1-methyl-1H-imidazole-2-carbaldehydeHCID 517045Sodium Acetate

Product 1

HCID 473918HCID 473918, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 2 ml of ethanol was dissolved 50 g (0.17 mmol) of 5-(3,5-dimethylphenylthio)-4-isopropyl-1-methyl-1H-imidazole-2-carbaldehyde (Compound I-6), followed by addition of 36 mg (0.5 mmol) of hydroxylamine hydrochloride and 43 mg (0.5 mmol) of sodium acetate, arid the mixture was stirred for 30 minutes at room temperature. To this reaction mixture, water was added, and the mixture was extracted with methylene chloride.

Workup

  1. extractionthe mixture was extracted with methylene chloride

Sources & evidence

ORD record
ord-e2df6480c04445eab2c0ca3071d3ab9f
Source dataset
uspto-grants-2000_11
Patent number
US06147097

Reaction notes

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