Hydrochloric Acid → Benzeneacetic acid, alpha-methyl-, ethyl ester

HRID 1857846Notes

Reaction equation

HRID 1857846 reaction equation
[C:1]1([CH:7]([CH3:11])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH2:13](O)[CH3:14]>>[C:1]1([CH:7]([CH3:11])[C:8]([O:10][CH2:13][CH3:14])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 102962-Phenylpropionic acid

Product 1

HCID 99643Benzeneacetic acid, alpha-methyl-, ethyl ester

Procedure

Dissolve 2-phenylpropionic acid (30 g) in 2 B ethanol (100 mL and add anhydrous HCl (10 g). Allow to sit for 48-72 hours, evaporate the solvent in vacuo and purify by distillation to give ethyl 2-phenylpropionate (31 g); bp 100 C. at 6 mm.

Workup

  1. customevaporate the solvent in vacuo
  2. distillationpurify by distillation

Sources & evidence

ORD record
ord-6e8c2d1684634a1cb0e6edf935bc6215
Source dataset
uspto-grants-2000_11
Patent number
US06147216

Reaction notes

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