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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1857862Generated: October 31, 2026

Ethanol → 2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

https://huagongshe.com/reaction/1857862

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanolHCID 702—
ReactantWaterHCID 962—
Reactant4-(Cyclopropylcarbonyl)-alpha,alpha-dimethylbenzeneacetonitrileHCID 23499845—
SolventPotassium HydroxideHCID 14797—
Product2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamideHCID 23499851—

Reaction Steps

Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methylpropionitrile (100 mg) in aqueous ethanolic potassium hydroxide (2 mL) (prepared from ethanol (5 mL), water (5 mL) and solid potassium hydroxide (1.5 g). Stir overnight at room temperature, then heat at reflux for 6 hours. Cool and evaporate the solvent in vacuo to give the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06147216
Source datasetuspto-grants-2000_11
ORD IDord-892028779b134d87b684355ab33bf8e2
Source noteuspto-grants-2000_11