反应详情

1.3 g (4.6 mmol) of 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-2-pyrrolecarboxaldehyde and 50 ml of THF are introduced into a three-necked flask under a stream of nitrogen. 300 mg (10 mmol) of sodium hydride (80% in oil) are added portionwise and the mixture is stirred until the evolution of gas has ceased. 640 μl (10 mmol) of iodomethane are then added and the mixture is stirred at room temperature for one hour. The reaction medium is poured into water and extracted with ethyl acetate, and the organic phase is separated out after settling has taken place, dried over magnesium sulphate and evaporated. The residue obtained is purified by chromatography on a column of silica eluted with a mixture of dichloromethane and heptane (70/30). After evaporation of the solvents, 600 mg (44%) of the expected product are collected.

1. stirringthe mixture is stirred at room temperature for one hour
2. extractionextracted with ethyl acetate
3. customthe organic phase is separated out after settling
4. dry with materialdried over magnesium sulphate
5. customevaporated
6. customThe residue obtained
7. customis purified by chromatography on a column of silica
8. washeluted with a mixture of dichloromethane and heptane (70/30)
9. customAfter evaporation of the solvents, 600 mg (44%) of the expected product
10. customare collected