HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-1H-pyrrole-2-carbaldehyde → 4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-2-pyrrolecarboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-1H-pyrrole-2-carbaldehyde | HCID 599627 | — |
| Reactant | (3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)boronic acid | HCID 10037535 | — |
| Product | 4-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-2-pyrrolecarboxaldehyde | HCID 22131507 | — |
Reaction Steps
In a similar manner to Example 3(b), by reaction of 2.47 g (10 mmol) of 3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthylboronic acid with 1.5 g (8.4 mmol) of 4-bromo-2-pyrrolecarboxaldehyde, 950 mg (38.5%) of the expected aldehyde are obtained, with a melting point of 128-9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06147255 |
| Source dataset | uspto-grants-2000_11 |
| ORD ID | ord-15a2cf59f2944c7ca539ecada961c14a |
| Source note | uspto-grants-2000_11 |