反应详情

To an ice-cooled solution of compound 2 (4.17 g) in isopropanol (80 ml) was added fumaric acid (1.26 g), and the mixture was stirred at room temperature for 8 hours. The resulting crystals were collected by filtration, and dried under reduced pressure to give fumarate hydrate (4.14 g) of compound 2 as white crystals.

1. filtrationThe resulting crystals were collected by filtration
2. customdried under reduced pressure