Potassium Hydroxide → 6-(1,4-Dioxa-8-azaspiro[4,5]dec-8-yl)-1,3,5-triazine-2,4-diamine

HRID 1857942Notes

Reaction equation

HRID 1857942 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4](Cl)[N:3]=1.[O:10]1[C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[O:13][CH2:12][CH2:11]1.[OH-].[K+]>O1CCOCC1.C(O)C.O>[O:10]1[C:14]2([CH2:19][CH2:18][N:17]([C:4]3[N:3]=[C:2]([NH2:1])[N:7]=[C:6]([NH2:8])[N:5]=3)[CH2:16][CH2:15]2)[O:13][CH2:12][CH2:11]1

Participants

7

Reactant 3

HCID 14797Potassium HydroxideHCID 188311,3,5-Triazine-2,4-diamine, 6-chloro-HCID 674351,4-Dioxa-8-azaspiro(4.5)decane

Product 1

HCID 98164366-(1,4-Dioxa-8-azaspiro[4,5]dec-8-yl)-1,3,5-triazine-2,4-diamine

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

A mixture of 2,4-diamino-6-chloro-1,3,5-triazine (2 g, 14 mmol), 1,4-dioxa-8-azaspiro[4.5]decane (3 g, 21 mmol), and KOH (100 mg, 1.8 mmol) in dioxane (10 mL) and ethanol (40 mL) was heated at reflux overnight, diluted with water, and filtered. The precipitate was rinsed with water and dried under vacuum to provide the title compound.

Workup

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. filtrationfiltered
  4. washThe precipitate was rinsed with water
  5. customdried under vacuum

Sources & evidence

ORD record
ord-698fd8cabfbe49b284e7f0777a4faaf4
Source dataset
uspto-grants-2000_11
Patent number
US06150362

Reaction notes

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