m-Chloroperbenzoic acid → HCID 22124952, compound

HRID 1857955Notes

Reaction equation

HRID 1857955 reaction equation
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([S:12][CH3:13])[CH:10]=2)[N:5]=[C:4]([C:14]([F:17])([F:16])[F:15])[N:3]=1.ClC1C=CC=C(C(OO)=[O:26])C=1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([S:12]([CH3:13])=[O:26])[CH:10]=2)[N:5]=[C:4]([C:14]([F:15])([F:17])[F:16])[N:3]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 22124935HCID 22124935, compound

Product 1

HCID 22124952HCID 22124952, compoundYield 49%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 4-chloro-6-methylthio-2-trifluoromethylquinazoline (0.4 g, 1.4 mmol) and m-chloroperbenzoic acid (0.3 g, 1.4 mmol) in chloroform (14 mL) was stirred at 0° C. for 0.5 h. The reaction mixture was washed with saturated sodium bisulfite solution, 1M sodium bicarbonate solution, and brine. The solution was dried (Na2SO4), filtered, and concentrated to give the title compound (0.2 g, 49%); m.p. 105-107° C.

Workup

  1. washThe reaction mixture was washed with saturated sodium bisulfite solution, 1M sodium bicarbonate solution, and brine
  2. dry with materialThe solution was dried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-28415adfa2bb4654a76ccb756e44ed5e
Source dataset
uspto-grants-2000_11
Patent number
US06150372

Reaction notes

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