Nitric Acid → HCID 22124232, compound

HRID 1857969Notes

Reaction equation

HRID 1857969 reaction equation
[N+:1]([O-:4])(O)=[O:2].[Cl:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:16]([Cl:17])[C:15]([OH:22])([C:18]([F:21])([F:20])[F:19])[O:14][N:13]=2)=[CH:8][CH:7]=1>S(=O)(=O)(O)O>[Cl:17][CH:16]1[C:15]([OH:22])([C:18]([F:19])([F:20])[F:21])[O:14][N:13]=[C:12]1[C:9]1[CH:10]=[CH:11][C:6]([Cl:5])=[C:7]([N+:1]([O-:4])=[O:2])[CH:8]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 22124231HCID 22124231, compound

Product 1

HCID 22124232HCID 22124232, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Conditions

Temperature
5 °C

Procedure

At 5° C., 1.81 ml of a mixture of 0.46 ml of 98% strength nitric acid and 1.35 ml of concentrated sulfuric acid were added dropwise to 2.4 g of 3-(4'-chlorophenyl)-4-chloro-5-hydroxy-5-trifluoromethylisoxazoline in 20 ml of concentrated sulfuric acid. The reaction mixture was stirred at 5° C. for 1.5 hours and then poured into 300 ml of ice-water. The organic phase was subsequently separated off, dried over sodium sulfate and finally concentrated. Yield: 2.5 g.

Workup

  1. customThe organic phase was subsequently separated off
  2. dry with materialdried over sodium sulfate
  3. concentrationfinally concentrated

Sources & evidence

ORD record
ord-00fe5474f17b45f3a9cd9dcb0e8232ca
Source dataset
uspto-grants-2000_11
Patent number
US06150303

Reaction notes

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