Nitric Acid → HCID 22124232, compound

Participants

Reaction Conditions

Reaction Steps

At 5° C., 1.81 ml of a mixture of 0.46 ml of 98% strength nitric acid and 1.35 ml of concentrated sulfuric acid were added dropwise to 2.4 g of 3-(4'-chlorophenyl)-4-chloro-5-hydroxy-5-trifluoromethylisoxazoline in 20 ml of concentrated sulfuric acid. The reaction mixture was stirred at 5° C. for 1.5 hours and then poured into 300 ml of ice-water. The organic phase was subsequently separated off, dried over sodium sulfate and finally concentrated. Yield: 2.5 g.

Provenance & Evidence