Nitric Acid → 6-(4,5-Dimethoxy-2-nitrophenyl)hexanoic acid

HRID 1858046Notes

Reaction equation

HRID 1858046 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[N+:19]([O-])([OH:21])=[O:20]>C(O)(=O)C>[CH3:10][O:9][C:8]1[C:3]([O:2][CH3:1])=[CH:4][C:5]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])=[C:6]([N+:19]([O-:21])=[O:20])[CH:7]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 45773436-(3,4-dimethoxyphenyl)hexanoic Acid

Product 1

HCID 221257506-(4,5-Dimethoxy-2-nitrophenyl)hexanoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a solution of 6-(3,4-dimethoxyphenyl)hexanoic acid (2.7 g) in acetic acid (10 ml) was added nitric acid (5.4 ml of a 2 M solution in acetic acid) and the mixture stirred at room temperature for one hour. The mixture was evaporated and the product used as such for the next step. Yield: 3.2 g.

Workup

  1. customThe mixture was evaporated

Sources & evidence

ORD record
ord-9e398f8181fd479ea2eab38954b815c7
Source dataset
uspto-grants-2000_11
Patent number
US06150412

Reaction notes

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