Pentylamine → 1-Octyl-3-pentylurea

HRID 1858047Notes

Reaction equation

HRID 1858047 reaction equation
[CH2:1]([NH2:6])[CH2:2][CH2:3][CH2:4][CH3:5].[CH2:7]([N:15]=[C:16]=[O:17])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]>CCCCCC>[CH2:7]([NH:15][C:16]([NH:6][CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[O:17])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

4

Reactant 2

HCID 8060PentylamineHCID 76616Octyl isocyanate

Product 1

HCID 98376951-Octyl-3-pentylureaYield 97%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

To 0.262 g (3.00 mmol) of pentylamine in 20 mL of hexane is added 0.53 mL (0.47 g, 3.0 mmol) of octylisocyanate with stirring to eventually produce a white crystalline solid. After standing overnight the mixture is cooled, the solid product collected, and washed with cold hexane. On air drying there is obtained 0.705 g (2.91 mmol, 97%) of 1-octyl-3-pentylurea as very fine white needles, mp 65.0-65.5° C. The material displays a 13C-NMR and a mass spectrum consistent with the assigned structure. 13C-NMR (CDCl3): δ 159.0 (C=O), 40.47 and 40.45 (C-1 and C-1'), 31.8 (C-6 and C-3'), 30.4 (C-2),30.1 (C-2'), 29.3 (C-4), 29.2 (C-5), 27.0 (C-3), 22.5 (C-7), 22.4 (C-4'), 13.9 (C-8 and C-5'); important infrared absorption bands (KBr disc) are present at 3334 (s, N--H), 1617 (vs, C=O), and 1579 (vs, amide II) cm-1.

Workup

  1. customto eventually produce a white crystalline solid
  2. temperaturethe mixture is cooled
  3. customthe solid product collected
  4. washwashed with cold hexane
  5. customOn air drying there

Sources & evidence

ORD record
ord-b3b8e3705a7844a3be5e53be119e62ea
Source dataset
uspto-grants-2000_11
Patent number
US06150415

Reaction notes

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