Methyl 4-ethynylbenzoate → HCID 54116665, compound

HRID 1858053Notes

Reaction equation

HRID 1858053 reaction equation
I/[CH:2]=[CH:3]/[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1.[C:17]([C:19]1[CH:28]=[CH:27][C:22]([C:23]([O:25]C)=[O:24])=[CH:21][CH:20]=1)#[CH:18]>>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[CH:2][C:18]#[C:17][C:19]2[CH:28]=[CH:27][C:22]([C:23]([OH:25])=[O:24])=[CH:21][CH:20]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 640163Methyl 4-ethynylbenzoateHCID 22125809HCID 22125809, compound

Product 1

HCID 54116665HCID 54116665, compoundYield 42.2%

Procedure

In a similar manner to that of Example 1(e), by reaction of 2.40 g (7.0 mmol) of 2-((E)-2-iodovinyl)-4'-chlorobiphenyl obtained in Example 23(b) with 1.03 g (6.4 mmol) of methyl 4-ethynylbenzoate, 970 mg (41%) of the expected compound are obtained in the form of a pale yellow solid with a melting point of 135° C.

Sources & evidence

ORD record
ord-dfde136d30ac4a9d9b2d553afc282204
Source dataset
uspto-grants-2000_11
Patent number
US06150413

Reaction notes

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