HRID1858067

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID260

Hydrogen Bromide

BrH

结构：Cc1cc(C)cc(-c2c(OCCC3CCCCN3C(=O)OCc3ccccc3)c3cc(NC(=O)Nc4ccncc4)c(Cl)cc3[nH]c2=O)c1

HCID54390580

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C)cc(-c2c(OCCC3CCCCN3)c3cc(NC(=O)Nc4ccncc4)c(Cl)cc3[nH]c2=O)c1

HCID9959121

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

A solution of 2-{2-[7-chloro-3-(3,5-dimethylphenyl)-2-oxo-6-(3-pyridin-4-yl-ureido)-1,2-dihydroquinolin-4-yloxy]-ethyl}-piperidine-1-carboxylic acid benzyl ester in 3 mL of a 30% solution of hydrobromic acid in acetic acid was stirred at room temperature for 3 hours then concentrated in vacuo. The residue was treated with saturated sodium bicarbonate and then extracted with ethyl acetate. Purification of the concentrate by flash chromatography on silica gel (methylene chloride:methanol:ammonium hydroxide, 96:3:1) gave the title compound.

WORKUP

后处理

concentrationthen concentrated in vacuo
additionThe residue was treated with saturated sodium bicarbonate
extractionextracted with ethyl acetate
customPurification of the
concentrationconcentrate by flash chromatography on silica gel (methylene chloride:methanol:ammonium hydroxide, 96:3:1)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5dde6b86068d4991a69c9914d8770feb
来源数据集: uspto-grants-2000_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06150352
来源说明: uspto-grants-2000_11

反应 SMILES

C(OC([N:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]1[CH2:17][CH2:18][O:19][C:20]1[C:29]2[C:24](=[CH:25][C:26]([Cl:40])=[C:27]([NH:30][C:31]([NH:33][C:34]3[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=3)=[O:32])[CH:28]=2)[NH:23][C:22](=[O:41])[C:21]=1[C:42]1[CH:47]=[C:46]([CH3:48])[CH:45]=[C:44]([CH3:49])[CH:43]=1)=O)C1C=CC=CC=1.Br>C(O)(=O)C>[Cl:40][C:26]1[CH:25]=[C:24]2[C:29]([C:20]([O:19][CH2:18][CH2:17][CH:12]3[CH2:13][CH2:14][CH2:15][CH2:16][NH:11]3)=[C:21]([C:42]3[CH:47]=[C:46]([CH3:48])[CH:45]=[C:44]([CH3:49])[CH:43]=3)[C:22](=[O:41])[NH:23]2)=[CH:28][C:27]=1[NH:30][C:31]([NH:33][C:34]1[CH:35]=[CH:36][N:37]=[CH:38][CH:39]=1)=[O:32]