Methyl 2-amino-4-chloro-5-iodobenzoate → Methyl 4-chloro-2-(2-(5-chlorothiophen-2-yl)acetamido)-5-iodobenzoate

HRID 1858175Notes

Reaction equation

HRID 1858175 reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH2:12].[Cl:14][C:15]1[S:19][C:18]([CH2:20][C:21](Cl)=[O:22])=[CH:17][CH:16]=1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[C:8]([I:10])[C:7]([Cl:11])=[CH:6][C:5]=1[NH:12][C:21](=[O:22])[CH2:20][C:18]1[S:19][C:15]([Cl:14])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 10852539Methyl 2-amino-4-chloro-5-iodobenzoateHCID 15740376(5-Chlorothiophen-2-yl)acetyl chloride

Product 1

HCID 54342187Methyl 4-chloro-2-(2-(5-chlorothiophen-2-yl)acetamido)-5-iodobenzoateYield 74.1%

Procedure

Prepared essentially as described in EXAMPLE 1, Step A from 5.0 g 2-amino-4-chloro-5-iodobenzoic acid methyl ester and 2.8 g (5-chlorothiophen-2-yl)acetyl chloride (also prepared essentially as described in EXAMPLE 1) to give the title compound (5.0 g).

Workup

  1. customPrepared essentially
  2. customalso prepared essentially

Sources & evidence

ORD record
ord-c94f2dc00763418abd9246833bf04889
Source dataset
uspto-grants-2000_11
Patent number
US06150522

Reaction notes

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