HCID 15351904, compound → HCID 15385697, compound

HRID 1858357Notes

Reaction equation

HRID 1858357 reaction equation
[O:1]1[C@@H:13]2[C@@:14]34[CH2:16][CH2:17][N:18]([CH3:19])[C@@H:8]([C@@H:9]3[CH:10]=[CH:11][C@@H:12]2[O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[CH2:7][C:6]2=[C:15]4[C:2]1=[C:3]([O:27][CH2:28][O:29][CH3:30])[CH:4]=[CH:5]2>CO.[Pd]>[O:1]1[C@@H:13]2[C@@:14]34[CH2:16][CH2:17][N:18]([CH3:19])[C@@H:8]([C@@H:9]3[CH2:10][CH2:11][C@@H:12]2[O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[CH2:7][C:6]2=[C:15]4[C:2]1=[C:3]([O:27][CH2:28][O:29][CH3:30])[CH:4]=[CH:5]2

Participants

4

Reactant 1

HCID 15351904HCID 15351904, compound

Product 1

HCID 15385697HCID 15385697, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4,5α-Epoxy-3-methoxymethoxy-17-methyl-6α-((2-pyridyl)-oxy)-morphinan-7-ene (1.0 g. 2.46 mmol) is dissolved in MeOH (40 ml), mixed with 10% Pd unactivated charcoal 800 mg and then agitated at RT under H2 (1 bar over pressure) for 2 hours. The catalyst is eliminated by filtering over a filter compound and a filtrate is concentrated by rotary evaporation.

Workup

  1. filtrationby filtering over a filter compound
  2. concentrationa filtrate is concentrated by rotary evaporation

Sources & evidence

ORD record
ord-22a0e1bda73c4640bf1c4bad5e01b6cc
Source dataset
uspto-grants-2000_11
Patent number
US06150524

Reaction notes

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